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Savior of Blood Cancer - Lu Dao-Pei
[Bone Marrow Transplantation Authority Helps Countless Cancer Patients


Are there any differences between easy and difficult things in the world? As long as you do them, difficult things will become easy; otherwise, easy things will become difficult
                                                 
   - Lu Dao-Pei

Founder of BMT saves countless lives
Lu Dao-Pei, an academician of the Chinese Academy of Engineering has devoted himself in the medical industry for more than 60 years. He is the founder of bone marrow transplantation (BMT) in mainland China. He tells everyone he meets: “My ideal of life is to help the sick and provide a patient-centered medical career.”

Academician Lu Dao-Pei is a well-known expert in hematology, hematonosis, and hematopoietic stem cell transplant (HSCT) in mainland China. He has devoted himself to medical affairs for more than 60 years.

Since 1957, he has been engaging in clinical and experimental studies of hematology and hematonosis, thereby creating his HSCT career in mainland China. He now continues to promote its development, and has made excellent contributions to the treatment of allogeneic hematopoietic stem cell transplant (allo-HSCT) and Chinese medical treatment of acute promyelocytic leukemia.

Nine firsts in the world
Lu Dao-Pei’s major achievements include: first successful development of syngeneic BMC in Asia; first successfully attempt in activated allo-HSCT in mainland China; first successfully achievement in major blood types ABO mismatched bone marrow transplantation in mainland China; and has made various contributions in initiating, establishing, fundraising, etc. in the Chinese bone marrow bank. He is the first person to proof that arsenic sulfide is highly effective against certain types of leukemia.
 
He initially established the umbilical cord blood hematopoietic stem cell bank in mainland China; first to apply some new immunotherapy methods to treat acute leukemia and achieved remarkable results; first to discover three kinds of hereditary blood disorders in mainland China; first to report that Lithospermum erythrorhizon and its extract have significant effect on Anaphylactoid purpura and phlebitis; first to brief on the use of peripheral blood stem cells in place of bone marrow as the source of HSCT in National Laboratory Hematology Association where this technology was named as “one of China’s top ten medical science news in 1996;” and he leads the country and even the world in HLA semi-identical transplantation standards.


Academician Lu Dao-Pei successively took the post of Vice President of the Chinese Medical Association, Chairman of the Chinese Society of Hematological Malignancies, Chinese Anti-Cancer Association, and the Vice Chairman of the China Internal Organ Transplant Institution. In 1995, he was elected as the only member of the International Marrow Transplant Registration Group Expert Steering Committee in China. He is also the Editor in Chief, Deputy Editor in Chief or Editor of eight domestic medical journals, and an editorial member of two international journals such as “Bone Marrow Transplantation (BMT)” and “Hematology Treatment,” and has published more than 360 articles/sections of articles, including four editorials such as “Leukemia Therapeutics,” and has participated in the preparation of 19 books.

In 2007, Lu Dao-Pei announced the establishment of the Chinese Society of Blood and Marrow Transplantation (CSBMT). He has received a number of distinctions including the National Health Science Conference on Medicine, National Second Prize of Promotion in Science & Technology Progress (ranked first place), the 7th Chen Jia-gen Prize for Promotion in Medicine & Pharmacy, the 3rd Ho Leung Ho Lee Foundation Science and Technology Progress Award, the Chinese Medical Association Science and Technology Progress Award, Beijing Science and Technology Progress Award (ranked first place), etc.
 
Still visiting the wards at 86 years old and won the CIBMTR Contribution Award
On February 20, 2016, the Center for International Blood & Marrow Transplant Research awarded the Distinguished Service Award to Academician Lu Dao-Pei. This is also the first time that an expert from mainland China has won this honor.
 
The most valuable thing is that Hebei Yanda Lu Daopei Hospital, located in the suburbs of Yanjiao District was established by Lu Dao-Pei and he acts as the legal person of Corporate Blood Specialist Hospital. Since the hospital was admitted to Yanda Hospital in April 2012, patients with blood diseases attending the hospital have been increasing year by year. Aged 86 this year, Academician Lu Dao-Pei is still working in the hospital’s outpatient clinic every Tuesday afternoon, and personally checks around the wards in the morning.

Lu Dao-Pei has devoted his entire life to medical services. For over 60 years, he has helped tens of thousands of cancer patients. Although he is nearly 90 years old now, he still concerns about the patients who come to seek treatment. He personally sits in the clinic and inspects the cancer wards every week, and cheers up all cancer patients. He also writes inspirational calligraphy to encourage himself and tens of thousands of cancer friends to face the diseases bravely and live in hopes. He deserves to be praised as a “Savior of Blood Cancer” and stood out among 2616 candidates of Loved Life Medal from all walks of life in the world and won the “21st Fervent Global Love of Lives Award” in 2018 from Chou, Ta-Kuan Foundation in Taiwan in advance on September 26, 2017.
 
The Foundation always welcomes recommendations for life warriors from all walks of life in the world who are hardworking, benevolent, courageous, and have made great accomplishments, etc. (Fervent Global Love of Lives Award recommendation hotline of Chou, Ta-Kuan Cultural and Educational Foundation of Taiwan: 02-29178770, Fax: 02-29178768, Address: 3F, No. 52, Mingde Road, Xindian District, New Taipei City, Website: http://www.ta.org.tw, e-mail: ta88ms17@gmail.com).
 
Medical family dedicating to medical science for over 60 years
Lu Dao-Pei’s ancestors came from Ningbo, Zhejiang Province. He was born in Shanghai on October 30, 1931.

From September 1948 to July 1949, he apprenticed at the Freshman Institute of Tongji University (Shanghai).
 
From September 1949 to May 1955, he apprenticed at Tongji Medical College, Tongji University (Shanghai, later moved to Wuhan); and the internship hospital in Shanghai Tongji Hospital (Rengyang Road), now known as the Shanghai Changzheng Hospital.

From 1955 to 1958, he worked as a Resident Physician of Internal Medicine at Beijing People’s Hospital (now renamed as Peking University People’s Hospital).

In 1980 and 1986, he received World Health Organization and Global Cancer Alliance scholarships and went to Hammersmith Hospital of Royal College of Physicians in London, and Brigham & Women Hospital of Harvard Medical School to major in leukemia and BMT.

From 1981 to February 2005: He served as the Director of Blood Disease Research Institute, Beijing Medical University
 
From 1985 to February 2005: He served as the Director of Internal Medicine, Peking University People’s Hospital
 
 In 1996, he was elected as an Academician of the Chinese Academy of Engineering and later served as a member of the Bureau.
 
 In 2002, he was elected as Vice President of the Asian Hematology Association (AHA) and recommended by the International Society of Hematology (ISH) as Chair of the 11th International Society of Hematology (ISH-APD) in the 2007 Conference.

Since 2005, he has been appointed as a Professor at Fudan University. He is also the Executive Director of the Chinese Medical Association and Director of the Medical Terms Verification Committee. He is currently a member of the Academic Committee of the Peking University Medical School, the Chief Expert of the National Key Division of Hematology of Peking University, and the Honorary Director of the Institute of Hematology of Peking University.

Highest priority to cure illnesses and save lives
Lu Dao-Pei’s parents had previously practiced medicine in Ningbo and later moved to Shanghai. He was born when the country was plunged into devastating turmoil after the “September 18th” Mukden Incident. When he returned to Shanghai after the Shanghai War, he found that his homeland has become rubble. Although he was academically obstructed, he later graduated first place from Shanghai Yihe Junior High School in 1948 due to his perseverance learning attitude. He was admitted to Tongji Medical College of Tongji University in the same year at the age of 17. Lu Dao-Pei was highly influenced by his ancestors since childhood who were doctors then and chose to cure illnesses and save people lives as his highest choice in career.

Lu Dao-Pei likes to read biographies since childhood, treats the honesty and diligence of characters in his biographies as models, and regards the scientists, in particularly, in the biographies as an example of his own pursuit. This has a profound impact on his life. The Tongji University he enrolled in was rigorous and admired academic freedom. One year after entering school, not only did he master English, but also had the ability to read various German specialized books.
 
Since his father was a Chinese medicine doctor and his elder brother was a medical student at St. John’s University, he had the opportunities to read both German and English books in various learning courses and learned Chinese medicine at the same time. The professors in the school taught them to learn more in three aspects: read more, think more, and practice more. His Pathology professor told him to look more at the autopsy of patients “because the level of consultation in a hospital is directly proportional to the number of anatomical cases.” Such similar education has a lifetime impact on him.

Systematic learning in life-saving work
     When he graduated from the medical school in 1955, he was able to read various English and German medical books skillfully, and he could also use dictionaries to read documents of the former Soviet Union. In his home, he still retains Deming’s General Chemistry which he read during junior high school, as well as university textbooks and reference books. This shows how he values the knowledge he learned before. Not only does he value the books, but also remember the contents in his mind.
 
After graduating from university, Lu Dao-Pei was assigned to the Central Ministry of Health and reassigned to the Central People’s Hospital (now the Peking University People’s Hospital). Besides visiting the wards every week for specific guidance, Dean Zhong Hui-Yi would also provide directional guidance after his inspection rounds. Lu Dao-Pei wrote when recalling the cultivation offered by Zhong Hui-Yi: “In addition to asking us to combine practical learning, Dr. Zhong also emphasized the need to study systematically. This has had a profound impact on me, leading me to finish reading Harrisons Principles of Internal Medicine, heart diseases, kidney diseases, endocrinology, tropical diseases, etc., followed by reading hemorrhagic diseases, hemolytic diseases, leukemia, and hematology experiments in advance before being promoted as Chief Resident Physician.
 
Lu Dao-Pei has deeply realized that “not only are the characters in the books useful, but the small characters in them can also benefit me a lot. I later have a close relationship with clinically intractable illnesses and rare diseases.”
 
Changed to Emergency Medicine’s night shift to learn from international blood experts during daytime
In the late 1950s, a Hungarian hematologist came to work at the People’s Hospital. Lu Dao-Pei learned from her blood morphology and coagulation tests, and also made important improvements in various detection methods. He has, in particular, made innovative changes to the calculation methods for prothrombin and antithrombin III. Later on, he had the opportunity to follow a Romanian hematologist who specializes in blood immunology. To win this learning opportunity, he changed to work from daytime clinic to Emergency Medicine’s night shift in order to have a chance to learn during the day.

After careful selection and recommendation by the Chinese Academy of Sciences, Lu Dao-Pei was awarded with the 7th Chen Jia-gen Foundation Prize for Promotion in Medicine & Pharmacy. The grand award ceremony was held in Singapore on April 22, 1998, where the auditorium was filled with VIPs and family members. Ong Teng Cheong, President of Singapore at that time personally awarded the gold medal with ribbons to Lu Dao-Pei who was seated on the rostrum.

Also attending the ceremony were Zhou Guangzhao, Vice Chairman of the National People’s Congress. Lu Dao-Pei first listened to the judges of the award, accepted the president’s award, and then bowed to the cheering crowd in the podium. That was a moment of grandeur, sacredness and excitement. At that moment, Lu Dao-Pei deeply felt that the accomplishments in his career were above all else, more important than any wealth or status in the world and what he has done is the right choice.
 
First Asian to help BMT cancer patients to live in hopes and always accompany them to overcome death
In the early 60s of the 20th century, Lu Dao-Pei began to research and succeeded the allogeneic bone marrow infusion treatment for aplastic anemia. In 1964, a nurse with severe aplastic anemia and having a pregnant identical twin then, sought medical help from him.

Lu Dao-Pei successfully performed a transplant on that patient. That operation set two world records and one Asian record for being the first safe use of pregnant women as donor, the first successful application of the lowest number of donor cells, and the first successful BMT in Asia.

Although that was a syngeneic transplant, Lu Dao-Pei creatively developed a number of techniques at that time. The patient’s hematopoietic function remained normal after 30 years of tracking, which was one of the two longest surviving cases in the world.
 
The hero spotted by WHO
At the beginning of the opening of reform in 1979, Lu Dao-Pei passed the WHO selection examination and was sent to London in 1980 to study the application of leukemia and hematopoietic stem cells for half a year. After half a year, he went to France, Switzerland, Germany, and other countries to study and make academic reports using the subsidy he saved.

In 1981, he succeeded in performing permanent implantation of his brother’s allogeneic bone marrow for a leukemia patient. Later, he also planted different mismatched bone marrow in living tissue, and was the first successful bone marrow transplantation in China with incompatible blood group. In 1985, he won the China Science and Technology Progress Award (second prize, ranking first). He was also the first to use peripheral blood stem cell transplantation to replace bone marrow stem cells. Up to the present day, Peking University People’s Hospital has made smooth progress in HSCT.

 Since then, he has trained a large number of technical teams of all units and the country in HSCT. In the early 90s of the 20th century, he called for the establishment of an unrelated volunteer hematopoietic stem cell donation registration group and the first non-blood related hematopoietic stem cell transplantation in China. Now, Chinese mainland volunteer organizations are thriving under the leadership of the Red Cross.
 
First to establish UCB hematopoietic stem cell bank
Since one-child families are the mainstream in China, it is increasingly difficult to find the same source of hematopoietic stem cells from their siblings. The rich hematopoietic stem cells in umbilical cord blood (UCB) of newborns has prompted Lu Dao-Pei to establish a public UCB Bank as early as 1996 by taking the internationally-established UCB Bank in New York as a blueprint.

The advantages of UCB hematopoietic stem cells coming from non-blood related donor to replace the hematopoietic stem cells are: readily available after cryopreservation, and the requirements for matching are not strict. The establishment of an UCB Bank provides an important solution to the problem of the lack of hematopoietic stem cell donors in China. UCB has a limited number of cells, so it is mostly used internationally for children. Lu Dao-Pei was the first successful person to use double-portion UCB internationally, and at the same time, successfully transplanted it to a patient weighing 95 kg.

Radical cure for leukemia
 In 1997 and 1999 at two annual hematology meetings of highest academic levels in the world, Lu Dao-Pei reported his many years of research results. He was the first to proof that purified arsenic tetrasulfide can allow long-term remission on certain acute leukemia. This report caused a lot of applause from the audiences and became the most noticeable news of the conference. Before that, Lu Dao-Pei had already reported this technique at several domestic and bilateral international conferences. His research was later published in May 2002 issue of Blood, the world’s highest-level journal of hematology.
 
In the eradication of leukemia, not only has Lu Dao-Pei developed drug therapy and HSCT, but also gained initial success to clinically use cell factor-initiated killer immune cells (CIK) to treat leukemia. After a patient who underwent allo-HSCT was treated with this therapy after an unfortunate relapse, the remaining leukemia cells were gone. He rejoined the leadership position and revived the once declining company.

Touching both sides of the strait
 Is Lu Dao-Pei smarter than others? He always denies affirmatively that he has never said he is smart. He only said that when he was still in school and was interrupted by some political movements, he would hide and read books secretly on the top floor of the building. While working and was assigned to kill the sparrows on the hospital’s rooftop, (during the campaign against four pests in that time, sparrows were considered as a kind of terminating object) he would also hide and read books under the roof. It was his hard-working and sweating study method that has made him gain profound knowledge.
 
From his youth, he gave up a lot of material things. When he graduated from college, his mother wanted to buy a garden house for him on Hunan Road, Shanghai. He chose to be dispatched to work outside of Shanghai. Since then, he also declined to be recruited by the University of Hong Kong and Taiwan with lucrative salary.

His answer is clear: “My career is in Beijing, and my patients and students are there.” His achievements in his career did not live up to his own demands. He was even successively elected Vice Chairman of the Chinese Medical Association, Chairman of Hematology Association, Academician of the Chinese Academy of Engineering, and was the Editor in Chief and Deputy Chief Editor of various journals at home and abroad, as well as an Honorary Professor and Adjunct Professor for several famous universities both at home and abroad. In 1997, he was awarded with Ho Keung Ho Lee Foundation Scientific Progress Award and Chen Jia-gen Medical Award. Lu Dao-Pei, who seems to be a famous player, is still struggling to learn endlessly. He has touched both sides across the strait, and rocked the world!